To make a bad situation worse: (Cambridge Dictionary)
To make a disease worse: (Cambridge Dictionary)
To make worse or more severe; intensify, as anything evil, disorderly, or troublesome: (Dictionary.com)
To make worse, more serious, or more severe : to intensify unpleasantly. (Merriam – Webster)
If someone or something aggravates a situation, they make it worse. (Collins Dictionary)
Make (a problem, injury, or offence) worse or more serious. (Oxford Dictionaries)
Lessons from the leaders: How to aggravate customer pain for commercial gain.
How to Aggravate Top Bloggers So They’ll Never Help You.