To put in a state of extreme physical or nervous fatigue. (Merriam – Webster)
A state of being very tired in a nervous or slightly anxious (=worried and nervous) way after a lot of mental or physical effort. (Cambridge Dictionary)
Completely exhausted. (Oxford Dictionaries)
To make or become exhausted or weary; tire out. (Collins Dictionary)
The Self-Care Project: How to let go of frazzle and make time for you.
Conservative writer: Trump might fire Sessions to ’cause a frazzle’.