Something that makes you suffer. (Cambridge Dictionary)
A cause of persistent pain or distress. (Merriam – Webster)
Great suffering. (Merriam – Webster)
The state of being afflicted by something that causes suffering. (Merriam – Webster)
An affliction is something which causes physical or mental suffering. (Collins Dictionary)
A cause of pain or harm. (Oxford Dictionaries)
Enduring Affliction, Trials, and Discipline.
What Does the Bible Say About Affliction? – OpenBible.info.